CIP System and Its Operations

The operation of the CIP system requires the control of several conditions, i.e., the fluid flow rates and velocities, temperatures, cleaning times and the concentrations of the cleaning chemicals (detergents, caustic soda). Systems in the pharmaceutical and bio-pharmaceutical industries use higher velocities for process piping. In the case of tanks, the rates of flow of either water or cleaning solution are largely determined by the size of the tank, as well as the number and the properties of the spray devices.

These gadgets arrive in an assortment of plans. The customary spray ball is generally used and gives directional streams of water or cleaning arrangement from little, static spouts. Rotational gadgets give round shower designs and direct impingement spray devices present high-weight streams at low streams, turning through 360˚ The impingement spray gadgets speak to a contrasting option to the expulsion of soils or stores by falling water or cleaning arrangement that course dmown the sidewalls of the tanks or vessels. The temperature of the CIP procedure may fluctuate from 135 to 175˚F and control is normally critical. The essential heat transfer requests are met either by joining heat exchangers into the CIP framework, or by direct infusion of steam. Chemicals might be added using peristaltic, pneumatic stomach and additionally more exact metering pumps. Groupings of the cleaning solutions are observed and controlled by the estimation of the pH or electrical conductivity of the solution.

The CIP procedure includes an arrangement of cycles that incorporates an underlying and last deplete step, a pre-flush, wash and post-flush. The span of the flush and wash cycles fluctuate from 5 minutes to 60 minutes. In the pharmaceutical, bio-pharmaceutical, dairy and food industries, the CIP procedure may incorporate a purify cycle to lessen the levels of bacterial contamination. This cycle essentially utilizes watery arrangements of solid oxidants, for example, hydrogen peroxide, ozone, chlorine dioxide and other chlorine-containing compounds.

At the point when a sanitize cycle is incorporated, thorough last flush cycles are required to maintain a strategic distance from erosion of the stainless steel tanks, vessels and process funneling, because of the nearness of hints of the solid oxidant, especially the chlorine containing mixes or chloride ions.
To efficiently drain process equipment and process piping, the system design must allow the fluids to flow out. Avoid sections of the piping and equipment in which fluid flow is restricted. Split flow designs also adversely affect the flow of solution through a piping system. Any problem areas should be identified and the piping modified or an appropriate cleaning method developed. The pre-rinse uses recycled water to flush out loosely adhering particulates and soil. This water is often flows directly to the drains as it leaves the CIP system. Depending on the nature of fouling and deposits, the number of chemicals for the wash cycle is used. The post-rinse cycle provides the final flush for the system. The effluent from this cycle is then discharged to the drains and directed to a tank. The effluent may flow to the drain or recovery points under gravity, but some CIP systems include return pumps or eductor devices.

Clean in Place Systems

To improve product quality in manufacturing systems, Clean-in-place (CIP) technology offers significant advantages. Right from efficient and reliable cleaning of process equipment and piping to lower costs, they have much to offer. The controls provide variety of cycle times, temperatures, composition and concentration of cleaning solutions.  In order to reduce costs and control waste disposal these systems include current recycling and regeneration technologies.

The automatic, reproducible and reliable delivery of cleaning solutions improves both product quality and plant hygiene. The ability to clean a processing system, incorporating tanks, pumps, valves, filters, heat exchange units and process piping, significantly reduces cleaning costs. It also helps minimize the handling of chemicals to provide a safer environment for plant personnel. CIP systems must be included in the design of any new process system.

CIP systems have several designs. The “single-pass” and the “recirculating” configurations are often utilized in the processing industries, since both require minimal capital investment. They usually have a small footprint and are flexible, in that the unit can readily adjust to a range of cleaning protocols. However, the cost for the chemicals, water and steam and for disposal of the wastewater are higher than for other designs.

The food industry usually favors a ‘re-use design’ that provides recycling of the water and regeneration of the cleaning chemicals. These systems have a larger footprint and are at greater risk of cross-contamination.  It also lacks flexibility i.e. a single temperature and single concentration of cleaning solution is used for the whole process system.

The pharmaceutical and bio-pharmaceutical industries prefer to use a multi-tank configuration. They have independent, stainless steel tanks that hold water of different quality, e.g., deionized water (DI), hot or cold water for injection (WFI) and water from reverse osmosis units (RO). These multi-tank systems are operated as if they were single-use systems, the tanks being drained between subsequent programs to minimize cross-contamination. This system is capable of circulating small volumes of water at relatively high rates.

A single use unit developed for the use in dairy and food processing industries has recently found application in selected pharmaceutical industries. These systems reduce the consumption of water and chemicals.